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Sepsis blood test combined with artificial intelligence could provide early detection tool


Doctors say combining simple blood test with artificial intelligence could help diagnose and identify sepsis faster Patients at highest risk for serious complications.

Sepsis is a serious condition in which the body is unable to respond appropriately to an infection. It can progress to septic shock, damaging the lungs, kidneys, liver and other organs. When the damage is severe, it can lead to death; when it is severe, it can lead to death. It is estimated that 11 million sepsis-related deaths occur worldwide each year.

A new dual approach using blood tests and artificial intelligence could detect the condition earlier and save lives, experts say, combining unique molecular signatures of sepsis with artificial intelligence tools to predict someone’s risk of organ failure and death.

Their findings will be presented at the European Congress of Clinical Microbiology and Infectious Diseases in Barcelona next month.

“It is critical to identify patients with suspected sepsis before organ failure occurs,” said Dr. Lisa Mellhammar of Lund University in Sweden. “Given that Challenges related to timely diagnosis In fact, sepsis kills millions of people worldwide every year, so an alternative approach is urgently needed. “

Combining blood tests with personalized risk models “has the potential to save lives by providing more accurate sepsis diagnoses and identifying who is likely to go on to develop more severe clinical manifestations,” she said.

The researchers studied 1,364 plasma samples from adults with suspected sepsis admitted to the emergency room of Skåne University Hospital between September 2016 and March 2023. Of the 1,073 infected patients, 913 had sepsis.

The team then analyzed proteins associated with the body’s immune response to sepsis to see if there was a pattern. They created molecular signatures from the analysis that they used to train artificial intelligence models to predict who is likely to go into septic shock.

Patients were classified as low, moderate, or high risk for septic shock, and the technology was able to show the relationship between increased risk and increased mortality.

The researchers also identified a group of proteins that predict dysfunction in six different organ types, including the heart, liver and kidneys, and then placed patients into five risk categories based on their likelihood of developing organ dysfunction and infection, as well as their risk of death. category.

Mellhammar added: “Rapid testing could not only provide a more accurate diagnosis of sepsis, but also predict who is at greater risk of worse outcomes, which now appears to be possible. Any study like this will require clinical validation in these Many hurdles must be cleared before the biomarker can be used in the clinic. “But we envision this as a tool that can be deployed globally as the future of early detection of sepsis.”

Dr Ron Daniels, founder and co-chief executive of the British Sepsis Trust, said: “It is vital that we accelerate our understanding of sepsis and identify more quickly which patients require immediate attention. Make sure we save more lives while using antimicrobials.” Smarter.

“This research has huge potential to deepen our understanding of sepsis and may in time help us redesign clinical systems. As the authors acknowledge, sepsis is a complex syndrome and this technology is not yet available. Ready to go, but it’s a big step in the right direction.”

Meanwhile, NHS England is preparing to roll out “Martha’s Reign” Phase One From next month, patients with ill health and their loved ones will be entitled to an urgent second opinion on their care, with the initiative initially being rolled out to 100 UK hospitals starting in April.

The rollout is a direct result of pressure on politicians, NHS bosses and doctors by Guardian senior editor Merope Mills and her husband Paul Laity. tell a story Their 13-year-old daughter, Martha Died at King’s College Hospital from sepsis London 2021.



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