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Second person to receive pig heart transplant just dies


Lawrence Faucette, a 58-year-old patient with terminal heart disease who was the second person to receive a genetically engineered pig heart, died on October 30. according to a statement from the University of Maryland Medical Center in Baltimore, where the transplant was performed.

Faucette received the transplant on September 20 and survived for six weeks – shorter than the first recipient, although Maryland team taking extra precautionsInitially, Fawcett made progress after surgery. He was receiving physical therapy, spending time with his family and playing cards with his wife, according to the university. But in the days before his death, his heart began to show signs of organ rejection, in other words, his immune system recognized the pig heart as a foreign object and attacked it. Rejection is also the biggest challenge in traditional human organ transplantation.

Researchers at the University of Maryland Medical Center and elsewhere have been studying the possibility of transplanting animal organs into humans, known as xenotransplantation, as a way to alleviate human organ shortages. USAThere are more than 103,000 people on the national transplant waiting list, and 17 people die every day while waiting for an organ. Because donor organs are a scarce resource, doctors want to select patients for transplant who are likely to survive and go on to receive a transplant. The effect after the operation was very good.

When Fawcett first arrived at the University of Maryland Medical Center on September 14, he was in end-stage heart failure. His heart had stopped beating and he needed to be resuscitated, but he was deemed too sick to undergo a traditional heart transplant. Transplant surgery. The U.S. Food and Drug Administration then gave him emergency authorization to receive a genetically engineered pig heart in hopes of extending his life. According to the university, Fawcett agreed to the procedure after being fully informed of the risks.

During Fawcett’s first month of recovery, the pig heart performed well, with no initial signs of rejection, and Fawcett was even working toward regaining the ability to walk.

“We intend to conduct an extensive analysis to identify preventable factors in future transplants,” Mohammad Mohideen, who directs the university’s xenotransplantation program, said in a statement.

David Bennett, the first person to receive a genetically engineered pig heart, survived for two months after undergoing the groundbreaking surgery in January 2022. He died of sudden heart failure. The Maryland team concluded that Bennett was in poor health before the transplant and that the discovery of a swine virus in his transplanted heart may have contributed to his death.



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